I've changed my Best of Gaming list to the games I've played the most in 2010, rather than being limited to the games released in 2010 only. I take a lot of time with games nowadays; instead of buying the latest and just end up shelving it for later, I try to finish the games that I have now, and don't really care any more if it's old or new. After all, it's gaming time that matters the most to me, and if I don't spend a lot of time playing a particular game, then that game isn't really worth playing, LOL.
1.
Fallout 3 [PS3]

My Game of the Year, never mind if it was released back in 2008. I usually avoid first-person shooters because they make me dizzy and nauseous but
Fallout 3 changed all that; it actually
cured me of my FPS motion sickness problem. Damned if I know what took me so long to play this game. Yup, the game has tons of glitches but everything else about it--the concept and story, plus the
awesome 1940's-1950's music was compelling enough to keep me playing for hours on end, even coming to work with only about an hour's sleep in the process, heh. And then there's Dogmeat, which further took this game into the realm of pure awesomeness.
2.
Shin Megami Tensei: Persona 3 Portable [PSP]
The PSP version of
Shin Megami Tensei: Persona 3 keeps almost everything from the PS2 version intact, and adds a new character that opens up additional possibilities. The result is an excellent portable translation that makes the experience more streamlined while retaining all the complex
Persona gameplay of the original.

3.
Pokemon Heart Gold/Soul Silver [DS]
This is the definitive Pokemon game available for the Nintendo DS. With 493 Pokemon and a chance to revisit the Johto and Kanto regions, the games have more new features that make them practically almost endless, as well as an included
Pokewalker accessory that literally lets you take your favorite Pokemon with you anywhere.
4.
Fallout: New Vegas [PS3]
Not a true sequel to
Fallout 3, but more like a supplementary adventure,
Fallout: New Vegas uses the same engine and offers more new options. And as expected, it's as glitchy as
Fallout 3 but has tons of content and the promise of upcoming material to keep you going through the Mojave Wasteland. No complaints here, heh.

5.
Super Scribblenauts [DS]
The original
Scribblenauts was brilliant, but was horribly flawed when it came to gameplay controls. This sequel corrected all the control issues and adds adjectives to its already huge database of words, and the result is a superb game that
Scribblenauts was truly meant to be.
6.
Resident Evil 5: Gold Edition [PS3]
This Gold Edition of
Resident Evil 5 contains the same basic story, but it's the additional episodes and bonus content that stand out. Both of the new episodes feature the original RE heroine, Jill Valentine, and the extra features contain multiplayer modes and new costumes, making this the must-have version of the game.
7.
Pac-Man Championship Edition DX [PS3]
Having played the original arcade version during the goldern era of vidoegaming,
Pac-Man has earned its place as one of my all-time favorite games. This enhanced version adds plenty of features and different visual styles, but still has that arcade feel and gives plenty of incentive for playing again and again.

8.
Picross 3D [DS]
Picross was one of my best games of 2007, and remains a favorite to this day. This time around, Nintendo added a third dimension, resulting in even more complex-looking puzzles, yet still surprisingly simple and logical once you get the hang of it. Very addictive as always.
9.
Scott Pilgrim vs. The World: The Game [PS3]
It's the game that was everything
the movie wasn't, mainly because it was fun. This glorious tribute to 2D side-scrolling battlers has amazing chiptune music and loads of cartoony violence, including bonus features that will make you want to play "just one more time"
10.
3D Dot Game Heroes [PS3]
A great homage to 8-bit dungeon crawlers of the past,
3D Dot Game Heroes has a unique visual style of its own. Resembling a medieval RPG built entirely with LEGO bricks, the game lets you customize your own character and even lets you download character designs from other gamers.